Jon_C_memo_7


 * Historicizing a Project **

1809: //Philosophie Zoologique// published by Jean-Baptiste Lamarck, where he discusses his theory of evolution through acquired characteristics.

1859: //On the Origin of Species// published by Charles Darwin. Discussed evolution via natural selection.

1900: Re-discovery of Gregor Mendel's work on plant genetics, gave Darwinism the "boost" it needed to become the dominant model of biological evolution.

1928-1964: Lysenko's program in agriculture, based on Lamarckian inheritance mechanisms.

1939: Conrad Waddington coins the term "epigenetics," a combination of "genetics" and "epigenesis."

1939-1945: World War II, frame for "Hunger Winter" (1944-1945) starvation study in the Netherlands.

2002: Study linking epigenetics and schizophrenia published.

2003: Landmark Agouti gene expression based on epigenetic imprinting study published. (Jirtle, et. al)

2004: Vidaza, a chemotherapy drug with epigenetic mechanisms, approved by the FDA.

2006: Revlimid, another chemotherapy drug with epigenetic mechanisms, approved by the FDA.

2007: Epigenetic imprinting discovered to be effected by environmental toxin Bisphenol-A in prenatal environments.

2008: Netherlands starvation study published.

2008: Bisphenol-A information published (with concerns) by the NIH's National Toxicity Project.

Snapshot: (I need to think about a pivotal year, will post this later tonight.)